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KMID : 0359720120300020136
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Journal of the Korean Neurological Association
2012 Volume.30 No. 2 p.136 ~ p.140
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Epstein-Barr Virus Related Polymorphic Posttransplantation Lymphoproliferative Disease in a Patient with Latent Infection of JC Virus
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Bin Chang-Hun
Park Min-Su
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Abstract
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Posttransplantation lymphoproliferative disease (PTLD) is an important form of posttransplant malignancy and is
typically associated with Epstein-Barr virus (EBV). Progressive multifocal leukoencephalopathy (PML) is a
demyelination disease caused by infection of the John Cunningham (JC) virus. Both PTLD and PML occur in the setting
of an immunosuppressive state. Differentiating PTLD from PML is important because PTLD can be treated by reducing
immunosuppressant agents or anti-B-cell antibody therapy. We report a case of EBV-related PTLD in a patient with
latent JC virus.
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KEYWORD
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Epstein-Barr virus, John Cunningham virus, Posttransplantation lymphoproliferative dis
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